Method Validation and Anticorrosion Property of Extant and Expired Tramadol Hydrochloride and Paracetamol by UV Spectrophotometry

Abstract

Tramadol hydrochloride is an opioid analgesic which has a noradrenergic and serotonergic property that contributes to its analgesic activity and is used for the management of moderate to severe pain. In combination with the opioid analgesic, Paracetamol can also use in the management of post-surgical pain and palliative care in cancer patients. Disposing of expired medicines particularly those used in larger quantities results to financial loss and causes environmental damage. Hence it is necessary to investigate the effectiveness of expired drugs and access its reuse as a corrosion inhibitor which could reduce both financial and environment loss. In this study, a precise, accurate, and simple UV Visible spectrophotometry has been developed for the determination of expired and extant tramadol hydrochloride and paracetamol by UV-visible spectrophotometry.