Engineering Elasticity: Spanlastics as Smart Vesicular Systems for Enhanced Therapeutic Delivery- A Review

Abstract

Spanlastics are innovative, elastic Nano-vesicular carriers designed to improve medication delivery efficiency and overcome the constraints of traditional dosage forms. These systems are made up of non-ionic surfactants and edge activators, which exhibit high deformability and can penetrate biological barriers. Spanlastics may encapsulate both hydrophilic and lipophilic pharmaceuticals, which improves medication stability, bioavailability, and therapeutic efficacy. Their unique structure allows for regulated and targeted medication release, which reduces systemic side effects and dose frequency. In terms of toxicity, biocompatibility, and chemical stability, sapanlastics perform better than conventional vesicular systems. Ophthalmic, transdermal, oral, and nasal delivery methods have all shown encouraging outcomes. The improved permeability and retention properties of spanlastics make them an ideal smart vesicular system for site-specific drug delivery. All things considered, spanlastics offer better treatment results and patient compliance, marking a substantial leap in drug delivery based on nanotechnology. This review summarises composition, preparation methods, advantages, evaluation and applications of spanlastics systems.