Development and Characterization of Nabumetone Solid Dispersions for Enhanced Solubility and Dissolution Performance

Abstract

Objective of the present investigation was to improve the solubility of poorly water soluble drug Nabumetone by solid dispersion (SD) techniques using HPβCD and PVP as a hydrophilic carriers. Effect of polymer concentration and methods of preparation on solubility and dissolution rate enhancement were studied. The result of solubility study showed increase in solubility of Nabumetone with increase in concentration of HPβCD and PVP. It was found that the dissolution rate of Nabumetone from its Solid dispersion was dependent on the method of preparation of solid dispersions. Dissolution study revealed that the kneading technique was most convenient and effective method for solubility enhancement of poorly water soluble drug Nabumetone than solvent evaporation method. The prepared solid dispersion was characterized by differential scanning calorimetry, Infrared spectroscopy and X-ray diffraction study. The results of the in vitro drug release studies clearly demonstrated potential of hydrophilic HPβCD  in enhancing solubility and dissolution rate of Nabumetone.