Bioactivity and Biochemistry of Tinospora Cordifolia: A Review

Abstract

Ministry of Ayurvedic, Yoga, Naturopathy, Unani, Siddha and Homeopathy (AYUSH), Government of India designated T. cordifolia as medical herb of the 21st century because it is one of the most frequently used Ayurvedic medicines for the treatment of different health disorders. In study, it is reported to have anti-inflammatory, anti-diabetic, antimicrobial, analgesic, anti-tumour, anti-stress, neuroprotective, cardioprotective, immunomodulatory and rejuvenating effects. The most important groups of biomolecules are carbohydrates, proteins, lipids, nucleic acid, enzyme cofactor and secondary metabolites consisting of glycosides, tetrapyrroles, steroids, flavonoids, alkaloids, polyketides, non- ribosomal proteins and carotenoids. Tinospora cordifolia, having ethnomedicinally significance is a majorly used plant in Ayurvedic system of medicine as general tonic, immunomodulatory, hypoglycemic,
anti-inflammatory, anti-arithiritic, anticancer, antiulcer, antipyretic, analgesic, diuretic and hepatoprotective power. 50% ethanolic extract of Tinospora cordifolia (TCE) exhibits potential anti-proliferative, pro-apoptotic and anti-migratory activity along with differentiation and senescence inducing potential in glioblastoma cells. Glioblastomas are the most aggressive and highly invasive primary brain tumour types.