Formulation Development and Evaluations of Quetiapine fumarate Extended Release Tablet by using 23 Factorial design

Abstract

The primary goal of the current study was to create and assess extended- release matrix tablets containing quetiapine fumarate, which binds to serotonin 2A and dopamine type 2 receptors, using a 23 factorial design. Formulations with extended release supply a specified rate for a set amount of time. The matrix tablet was made using a wet granulation technique with ethyl cellulose, HPMC K100, and HPMC K15 polymer concentrations. The drug's compatibility with polymers and other excipients was assessed using DSC and FT-IR spectroscopy. The medication was shown to be compatible with polymers and other excipients.