Formulation and Evaluation Immediate Release Antidiabetic Tablet

Abstract

Alogliptin are used for involve the development of an oral dosage form aimed at managing Type 2 Diabetes Mellitus by inhibiting the enzyme Dipeptidyl Peptidase-4 (DPP-4). The objective of this study to design the formulate and evaluate film coated immediate release containing alogliptin antidiabetic drug. The prepared tablets were tested for their pharmacopoeial requirements. The UV spectroscopy method was developed based on quantitative estimation of alogliptin absorption at maximum wavelength 222nm by using methanol and water as a solvent. Different binders are used to help maintain gel structure by using HPC. Dry granulation and wet granulation are chosen for preparation of tablet were evaluated for their impact on tablet characteristics, including hardness, friability, disintegration time. Another objective of this study to provide pharmaceutical composition with high bioavailability, high physical and chemical stability and long shelf life. The tablets were subjected to stability testing, content uniformity to ensure they meet pharmacopoeials standards. Based on preliminary study and different formulation batches (F1-F6) were carried out. From the various formulation it was concluded that F6 batch showed satisfactory results.