Advances in Polyherbal Emulgel Systems for Topical Antifungal Therapy: A Comprehensive Review

Abstract

Emulgel is a cutting-edge topical drug delivery method that improves the distribution of hydrophobic medications by fusing the characteristics of gels and emulsions. The formulation, assessment, and therapeutic potential of polyherbal emulgels are the main topics of this review, especially with regard to antifungal applications. Patient compliance is decreased by the limits of conventional topical formulations, such as creams and ointments, which frequently include greasiness, poor spreadability, and stability problems. By offering greater drug loading, stability, penetration, and controlled release, emulgels get around these problems.

The review highlights the significance of penetration enhancers and the physiological and physicochemical characteristics that affect topical medication absorption. Based on their properties and capabilities, several emulgel types—such as microemulgels, nanoemulgels, and macroemulsion gels—are examined. Herbal extracts with strong antifungal and anti-inflammatory properties, such as Ocimum sanctum and Nyctanthes arbor-tristis, are included with particular care. The production process and evaluation criteria, including pH, globule size, spreadability, and medication content, are also described. All things considered, polyherbal emulgels present a viable, efficient, and patient-friendly method for topical antifungal treatment with possible future uses.