Formulation and Evaluation of Tinospora Cordifolia Loaded Nanosponges

Resumen

Background: Tinospora cordifolia, a natural product with numerous uses in traditional ayurvedic medicine, has gained global interest due to its active components and biological role in illness prevention.

Methodology: This study focuses on the formulation and evaluation of nanosponges loaded with Tinospora cordifolia extract, using an emulsion solvent diffusion method.  

Results and Discussion: SEM images revealed the nanosponges, which were visually inspectable through optical binocular microscopy. The F12 batch showed fine, spherical nanosponges with a maximum percentage yield of 74%. The nanosponges were porous, smooth, and spherical, with a particle size of 192.674 nm.

Conclusion: Diabetes mellitus may be treated with nanosponges loaded with Tinospora Cordifolia. This may lead to a decrease in insulin resistance and an increase in insulin receptor sensitivity on cells. Furthermore, it could lead to continuous drug delivery, which would lower dosage, frequency of administration, and adverse effects.