Synthesis and Characterization of A Novel Mannic Base Reaction and Its Zn Complex and Investigate the Anti-Cancer Activity of the Prepared Compounds against MCF-7

Resumen

One of the most common multicomponent reactions in organic chemistry is the Mannich
reaction. The Mannich product is generated in the original version of the reaction by the
reacting the acid C-H of formaldehyde, and a secondary amine. Mannich reaction was
employed in this research to synthesize 5-((4-phenylpiperazin-1-yl) methyl)-1H-pyrrole-2-
carbaldehyde (L1) by reacting Phenylpiperazine with formalin and pyrolcarbaldehyde.
Furthermore, the (L1) ligand reacts with Zn to form C1, complex. Elemental analysis, and
1HNMR, 13CNMR, spectroscopy were used to analyze the produced compounds. The anticancer
activity for L1 and C1 were investigated against breast cancer cell line MCF-7 invitro
and giving a good cytotoxicity in cancer cell line compared to normal cell line.