Evaluation of Endothelial Function and Connective Tissue Metabolism in Patients with Upper Git Pathology on the Background of Connective Tissue Dyplasia

Resumen

The aim of the study was to study the state of endothelial function, connective tissue
metabolism in patients with pathology of the upper gastrointestinal tract against the
background of connective tissue dysplasia in order to develop a system for managing patients
at the level of primary health care. The study revealed that in patients with gastrointestinal
pathologies associated with CTD, a decrease in the level of magnesium in the blood,
activation of hyaluronidase was established, which contributed to an increased breakdown of
the components of the extracellular matrix with an increase in the excretion of their decay
products. Endothelial dysfunction is also noted, due to an imbalance in the NO system. The
imbalance in the NO system, in turn, is determined by the overexpression of iNOS and the
accumulation of ONO2-, inhibition of eNOS activity.